Going in GTP cycles in the nucleolus
نویسنده
چکیده
Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.
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عنوان ژورنال:
- The Journal of Cell Biology
دوره 168 شماره
صفحات -
تاریخ انتشار 2005